Standard starting dose with options for dose management

STIVARGA® (regorafenib) dosing in the CORRECT, phase 3 trial

The recommended starting dose is 160 mg STIVARGA (four 40-mg tablets) taken orally once daily for the first 3 weeks, followed by a 1-week treatment break.1

STIVARGA (regorafenib) dosing schedule. Visit hcp.stivarga-us.com to see full safety and Prescribing Information, including Boxed Warning.

Dosage and administration for STIVARGA1

  • Treatment should continue until disease progression or until unacceptable toxicity occurs
  • STIVARGA should be taken whole with water after a low-fat meal that contains <600 calories and <30% fat at the same time each day 
  • Advise patients to take any missed dose on the same day, as soon as they remember, and that they must not take 2 doses on the same day to make up for a dose missed on the previous day
  • No dose adjustment is recommended for patients with renal impairment
  • The pharmacokinetics of STIVARGA have not been studied in patients who are on dialysis and there is no recommended dose for this patient population
  • No dose adjustments are required based on mild (total bilirubin ≤ upper limit of normal (ULN) and aspartate aminotransferase (AST) >ULN, or total bilirubin >ULN to ≤1.5x ULN) or moderate (total bilirubin >1.5 to ≤3x ULN and any AST) hepatic impairment. Closely monitor patients with hepatic impairment for adverse reactions. STIVARGA is not recommended for use in patients with severe hepatic impairment (total bilirubin >3x ULN), as STIVARGA has not been studied in this population

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) include the option for the following dose-escalation schedule (Category 2A)2,3*

Regorafenib (STIVARGA®) dose escalation schedule in mCRC

Alternate dosing schedule for STIVARGA® (regorafenib). Visit hcp.stivarga-us.com to see full safety and Prescribing Information, including Boxed Warning.

National Comprehensive Cancer Network (NCCN®) makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

  • Dosing escalation takes place during the first 4-week cycle (3 weeks on, 1 week off)2,3
  • Week 1: 80 mg of STIVARGA (two 40-mg tablets) taken orally once daily, Week 2: 120 mg (three 40-mg tablets), Week 3 dose is 160 mg (four 40-mg tablets), followed by Week 4 dose-free interval1-3
  • Subsequent cycles are dosed at the last dose from Cycle 12,3

Monitoring AEs is critical during the first cycle and throughout therapy