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*Not based on actual patient.
Stage IV rectal cancer
Sandra is a 67-year-old woman with stage IV, KRAS mutant rectal cancer. She developed recurrent disease with liver metastases 17 months after total resection and adjuvant chemotherapy.
- Diagnosed with mucinous adenocarcinoma of the rectum, she was successfully treated with total resection and adjuvant FOLFOX (12 cycles)
- 17 months later, she experienced recurrence with liver metastases in the VII and VIII segments, was treated with FOLFIRI + bevacizumab, and had a PFS of 12 months
- After a CT scan showed evidence of progressive disease in lymph nodes, she was treated with FOLFOX + bevacizumab
- KRAS mutant disease with no evidence of microsatellite instability or defective mismatch repair
- Patient’s disease recurred after 8 months with diaphragmatic and nodal progressive disease
Relevant medical history
- Hypertension controlled with diuretic/beta-blocker therapy (BP 138/89 mm Hg)
- ECOG performance status: 1